the coming implosion of biomedical & health science research

The state of health science in the US today is not weak, but it is under threat. The main problems: 1. p-value hacking. 2. commoditization of adjunct and postdoc labor. 3. disincentives of null value results or replication. All of these things threaten the foundations of the increasingly unsustaiunable edifice that is modern health science, and all of them derive in one way or another from the same root problem: the only source of objective funding, untainted by corporate interests, is the NIH. In essence, health science is a zero-sum game.

This is why the Trump Administration preliminary budget proposal is ominous: it specifies an unprecedented 18% cut to the NIH budget.

As the image above illustrates, grant applications have grown almost twice as competitive over the years as NIH funding stayed constant. An 18% cut in this context is like an amputation.

There is only one possible outcome of this: labs will shrink. Health science research is going to be dramatically curtailed. Maybe there are benefits, in the long run, to this – but in the short run it will only worsen – severely – the problems that health science research currently faces. The question is, how resilient is the health science establishment? We are going to find out.

Even though I left academia, I will be marching for science on Earth Day.

Related: great article at The Atlantic that points out how private funding is a drop in the bucket compared to government support. In my opinion, public science funding is as critical and as irreplaceable as national defense.

Space battles in The Expanse are incredible

watch this.

wow. that raises the bar in my imagination for any space battle in any sci fi. I’ll never be quite as enamoured of X-Wing dogfights ever again. The Expanse is true hard sci-fi in the TV era – there’s as much depth in the novels for a Game of Thrones-esque run if they do it right. Having read (most of) the books, I am amazed at how amazed I am at major plot developments in the show, even though I know they are coming – they just have such incredible impact.

Related: the Nauvoo is just… a cathedral of awesome.

Highlander reboot? there can be only one

zeist

What would a guy really be like after 500 years of practicing sword-work? I’m still a stunt guy at heart. You want to reinvent gunfights, how do you do it? You want to reinvent swordfighting, how do you do it? And that’s where we are at now. I love the first Highlander and I think I’m in a pretty good spot. The creative team, the producers and the studio that’s behind it have kind of said, ‘It’s yours to play with.’ The trick would be coming up with an interesting way to introduce it to new audiences without stepping on what’s great about the original property. You don’t want to over complicate it. I think it speaks very simply: ‘There can be only one!’ ‘We’re immortals!’ ‘Don’t get your head chopped off!’ I think we all know what happened with the sequels.”
[…]
“When I came on, the property had already been developed for a couple of years and, as things happen in Hollywood, yeah, there was aliens, meteors, spaceships, uh, DNA mutations, terrorists. I mean, they’d tried to drag every plot into the Immortal world. My personal opinion, I don’t want to see any of that. I’m not interested. I have seen other movies like that. I haven’t seen the Immortal world.”

(grudgingly) fine, do what you want. but there can still only be one.

Still, how do you do an interview with a director for a Highlander movie, reboot or otherwise, and not ask about Queen? SMH

Jack is back – March 11

50 years into the future, time has not been kind to Jack. Aku has destroyed all of the time portals, thwarting the journey to travel back in time and stop him. Now, Jack is immortal (as a side effect of the time travel), but broken and lost. Aku, similarly, has everything he could ever want and is equally miserable. It’s a dark vision, not just in terms of the world, but in the personal despair.

more.

Episodic_Photo_Samurai_Jack_copy